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doi:10.1161/ATVBAHA.107.152298 [PubMed][Crossref] 6

Long-term cognitive decline after newly diagnosed heart failure: longitudinal analysis in the CHS (Cardiovascular Health Study)

my understanding is the elevated B6 is because the pathways are blocked from the SIBO youre basically B6 deficient, even though you have high blood levels you need P5P which will bring it all back into line

Animal studies suggest it works through specific cellular signaling pathways (FAK-paxillin and ERK1/2) to ramp up this repair process